Publications & News

2016

DNA from dust: comparative genomics of large DNA viruses in field surveillance samples
Pandey U, Bell AS, Renner D, Kennedy DA, Shreve J, Cairns CL, Jones MJ, Dunn PA, Read AF,  Szpara ML – mSphere [PDF]

Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79
Bowen CD, Renner DW, Shreve JT, Tafuri Y, PayneKM, Dix RD, Kinchington PR, Gatherer D, Szpara ML – Virology (Elsevier) [PDF]

Differentiation of the SH-SY5Y human neuroblastoma cell line
Shipley MM, Mangold CA, Szpara ML – Journal of Visualized Experiments [PDF] [Movie]

2015

VirAmp: A Galaxy-based viral genome assembly pipeline
Wan Y, Renner DW, Albert I, Szpara ML – GigaScience [PDF]

Rapid genome assembly and comparison decodes intra-strain variation in human alpha-herpesviruses
Parsons LR, Tafuri YR, Shreve JT, Bowen CD, Shipley MM, Enquist LW, Szpara ML – mBio [PDF]

2014

Genome sequence of the anterograde-spread defective herpes simplex virus 1 strain MacIntyre
Szpara ML, Tafuri YR, Parsons L, Shreve JT, Engel EA, Enquist LW – Genome Announcements [PDF]

Isolation of Herpes Simplex Virus Nucleocapsid DNA
ML Szpara – Meth Molec Biol [PDF]

2013

Evolution and diversity in human herpes simplex virus genomes
ML Szpara, D Gatherer, A Ochoa, B Greenbaum, A Dolan, RJ Bowden, LW Enquist, M Legendre, AJ Davison – Journal of virology [PDF]

2011

Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication
AC Haugo, ML Szpara, L Parsons, LW Enquist, RJ Roller – Journal of virology [PDF]

A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses
ML Szpara, YR Tafuri, L Parsons, SR Shamim, KJ Verstrepen, M Legendre, LW Enquist – PLoS Pathogens [PDF]

Preparation of viral DNA from nucleocapsids
ML Szpara, YR Tafuri, LW Enquist – Journal of Visualized Experiments [PDF] [Movie]

2010

Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations
ML Szpara, L Parsons, LW Enquist – Journal of virology [PDF] [Data website]

A common neuronal response to alphaherpesvirus infection
ML Szpara, O Kobiler, LW Enquist – Journal of Neuroimmune Pharmacology [PDF]

2009

Fluorescence-based monitoring of in vivo neural activity using a circuit-tracing pseudorabies virus
AE Granstedt, ML Szpara, B Kuhn, SS Wang, LW Enquist – PLoS One [PDF]

Compartmented neuron cultures for directional infection by alpha herpesviruses
D Curanović, TH Ch’ng, M Szpara, L Enquist – Current Protocols in Cell Biology [PDF]

2007

Analysis of gene expression during neurite outgrowth and regeneration
ML Szpara, K Vranizan, YC Tai, CS Goodman, TP Speed, J Ngai – BMC neuroscience [PDF]

2004

Regulation of pontine neurite morphology by target-derived signals
SK Hansen, ML Szpara, TA Serafini – Molecular brain research [PDF]

2017

July:
-  Moriah Szpara will be giving the Priscilla Schaffer Memorial Lecture at the International Herpesvirus Workshop (IHW) in Ghent, Belgium.

June:
-  The lab will be represented at the ASM Microbe meeting in New Orleans, with posters presented by Utsav Pandey (grad student) & Kokila Shankar (senior undergraduate). Kokila will be participating in the Microbiology Academy for Professional Development (MAPD) Workshop at ASM, as part of her winning a 2016 ASM Undergraduate Research Fellowship.

–  The lab will be represented at the 2017 American Society for Virology (ASV) meeting in Madison, WI, with a short talk presented by Mackenzie Shipley.

May:
Moriah Szpara will give a talk at the Colorado Alphaherpesvirus Symposium (CALS).

– Our two senior undergraduates, Kokila Shankar & Chris Sharkey, have finished their Bachelor’s degrees! Kokila will be heading to graduate school and Chris to computational data science at Microsoft. Congratulations on your honors thesis Kokila (first in the lab!) and your computational manuscript draft Chris!

April:
-  Utsav Pandey did a great job with a full-length (45 min) seminar in BMB‘s 4th year graduate student seminar series. Kudos, Utsav!

– Moriah Szpara gave a talk at the University of Chicago interdisciplinary PhD program in Genetics, Genomics & Systems Biology (GGSB).

March:
-  Moriah Szpara gave a talk at the 9th Workshop in Virus Evolution, on our collaboration with Nancy Sawtell (Cincinnati Children’s Hospital) & Rick Thompson (University of Cinncinnati), which also involves Utsav Pandey & Daniel Renner.

February:
-   Mackenzie Shipley did a great job with her full-length (45 min) seminar, as part of BMB‘s 4th year graduate student seminar series. Kudos, Mackenzie!

2016

December:
-   Molly Rathbun joins the lab as our newest graduate student, from the BMMB graduate program. Molly has a background in forensics. Congratulations to Molly for being selected for the CBIOS Training Grant program!

November:
-   Chris Bowen gave a talk on our lab’s collaboration with Lynda Morrison, at the Penn State Intercampus Virology (PSIV) meeting — great job, Chris!

August:
-   Utsav’s paper on the capture and comparison of herpesvirus genomes from dust and feather has been accepted at mSphere. Congratulations to UtsavDaniel, Andy Bell, David Kennedy, and the team from the Read lab that contributed to this accomplishment!

–   Colleen Mangold received a fellowship from the American Heart Association! She will be one of the Great Rivers Affiliate Winter 2016 Postdoctoral Fellows, with a two year award. Our colleagues Tony Huang, David Hughes, and Stephen Benkovic contributed to the process as co-sponsors. Congratulations Colleen!

–   Chad Kuny joined the lab as a postdoc, bringing his expertise with beta-herpesviruses and more recently in RNA virology. Welcome Chad!

–  Utsav gave a talk at the MCIBS and Pathobiology Summer Retreat, sharing his MDV genomics research with the new recruits.

July:
-   Moriah Szpara was an invited speaker at the FASEB meeting on “Virus Structure and Assembly” from July 24‐29, in Colorado. Kudos to our colleague Rebecca Craven for her part in co-organizing this meeting.

–   Moriah Szpara presented Utsav’s research on MDV genome surveillance in the field, at the 11th International Symposium on Marek’s Disease and Avian Herpesviruses in France.

June:
Mackenzie Shipley presented a short talk on her new research on herpesvirus infection of human neurons at the University of Pennsylvania symposium entitled Herpesviruses: Pathogenesis and Cancer on June 24. This year’s symposium honored the career of our colleague Dr. Jim Alwine.

–   Moriah Szpara presented a poster during the Viral Genomics and Evolution meeting at the Wellcome Genome Campus in the UK. Kudos to our colleague Judy Breuer for her role in co-organizing this.

May:
-   Moriah Szpara chaired the 35th Annual Summer Symposium in Molecular Biology at the University Park campus, on the topic of Living with our Viromes. Kudos to all the lab members who chaired sessions, presented posters, hosted speakers and attendees, and helped make this a great event! The symposium took place May 24-25, 2016.

–  Congratulations to our undergraduate researcher Apoorva Talanki, on her recent graduation from Penn State!

– Moriah Szpara gave a talk about Mackenzie’s research at the Colorado Alphaherpesvirus Symposium (CALS).

April:
- Congratulations to Kokila Shankar, on winning a 2016 ASM Undergraduate Research Fellowship! This will support her summer research project, and attendance of the ASM Microbe meeting next year.

–   Mackenzie Shipley presented her data on HSV infection of human neuronal cells at the April meeting of Virology@PSU.

February:
-   Our video protocol on achieving full neuronal differentiation of human SH-SY5Y cells was published in JoVE. Congrats to Mackenzie Shipley and Colleen Mangold on putting this together!

–   Colleen Mangold presented on neuronal positioning via acoustofluidics at the February meeting of CMIND.

–   Utsav Pandey presented a summary of our MDV genomics collaboration with Andrew Read’s lab for the January meeting of Virology@PSU.

January:
-   Mackenzie Shipley presented her data on HSV infection of human neuronal cells at CMIND.

2015

December:
-   Colleen Mangold gave an overview on her progress in acoustofluidics with Tony Huang’s lab for the December meeting of Virology@PSU.

–   We made the first announcement of speakers for the “Living with our Viromes” symposium that Moriah Szpara is chairing, along with a team of co-conveners from Virology@PSU.

November:
-   Mackenzie Shipley gave her first ever hour-long seminar, in BMB‘s departmental graduate student seminar series. Well done!

–   The lab enjoyed a great day of cross-campus virology at the 2nd Penn State Intercampus Virology (PSIV) meeting. Over 60 people from labs spanning the University Park and Hershey College of Medicine campuses gathered for a day of science, networking, and talks by trainees. Colleen Mangold launched the day with her talk on acoustofluidics.

–   Congratulations to Kokila Shankar and Nathan Arnett, who each won a 2015-2016 Undergraduate Research Support Award from the Eberly College of Science!

October:
-  Colleen Mangold presented her work with Tony Huang’s lab with a poster at Neuroscience 2015, the 45th annual meeting of the Society for Neuroscience.

–  Utsav Pandey gave his first ever full-length talk as a graduate student, in BMB‘s departmental graduate student seminar series. Nicely done!

–  Moriah Szpara highlighted all the great virology action at Penn State (see: Virology@PSU) during a CIDD lunch with PSU President Eric Barron.

–  Kokila Shankar & Chris Sharkey presented their research projects at the Fall 2015 Science Undergraduate Poster Exhibition.

September:
-  Utsav Pandey reprised his MDV talk at the 2015 Northeastern Conference on Avian Diseases (NECAD).

–  Colleen Mangold gave a great talk on her work with Tony Huang’s lab at the annual retreat of Center for Molecular Investigation of Neurological Disorders (CMIND).

August:
-  Mackenzie Shipley successfully completed her comprehensive exam as a BMMB graduate student! Congratulations!

July:

–  Utsav PandeyMackenzie ShipleyDaniel Renner, & Moriah Szpara present new data at the International Herpesvirus Workshop (IHW) in Boise, ID. In addition to our four posters, Mackenzie’s abstract was selected for a travel award, and Utsav gave a talk in the Veterinary Herpesvirus Satellite Workshop.

–  Utsav Pandey successfully completed his comprehensive exam as a BMMB graduate student! Congratulations!

– Chris Bowen and Moriah Szpara present talks at the American Society for Virology (ASV) meeting in London, ON, Canada.

June:
-  Utsav Pandey and Mackenzie Shipley give talks at the inaugural PSU Intercampus Virology meeting, at the Penn State Hershey campus. Nicely done! The meeting on June 9 was organized by our colleagues John Wills & Becky Craven. The next one will be in November 2016 at the University Park campus.

– Mackenzie Shipley wins the department’s Paul M. Althouse Outstanding TA Award this year! This was based on her efforts in Fall 2014 and Spring 2015 in the “Protein Purification & Enzymology” lab.

– Utsav Pandey gives his first public research talk at a University of Pennsylvania symposium entitled Herpesviruses: Pathogenesis and Cancer on June 2. This year’s symposium honored the career of our colleague Dr. Nigel Fraser.

– Welcome to our newest undergraduate members of the lab: Kokila Shankar & Apoorva Talanki!

May:
-  Congrats to Colleen Mangold for winning a Huck Biotechnology Mini-grant, which will fund her confocal microscopy work at the Huck Microscopy & Cytometry Core Facility.

– Moriah Szpara gives a talk at the Colorado Alphaherpesvirus Symposium (CALS).

Daniel Renner gives a poster on VirAmp at the Great Lakes’ (GLBIO) meeting of the International Society for Computational Biology, at Purdue University.

– Congrats to our undergrads Nathan Arnett & Chris Sharkey on landing great summer interships. Nathan will be at the University of Pittsburgh Summer Undergraduate Research Program (SURP), and Chris has an internship at Humana.

April:
-  VirAmp is published — our first web-based tool for virus assembly. Congrats Yinan & Daniel!

March:
-  Moriah Szpara gave a talk at the 8th Workshop in Virus Evolution.

–  Our latest research is published in mBio — a lovely story about sister clones of various HSV strains.  The early stages of this project involved Lance Parsons and Yoly Tafuri, in Lynn Enquist’s lab at Princeton. The research was brought to fruition with the help of several members of the new team at PSU  — Jacob Shreve, Chris Bowen & Mackenzie Shipley. Nice teamwork!

– Congratulations to Mackenzie Shipley, on receiving an early registration abstract award for the International Herpesvirus Workshop in July 2015.

January:
-  Utsav Pandey and Mackenzie Shipley advance to PhD candidacy in the Biochemistry, Microbiology, and Molecular Biology graduate program. Congratulations!

Moriah Szpara & Craig Cameron co-teach MICRB 415, also known as General Virology, this semester.

2014

December:
Utsav Pandey presents a talk for Virology@PSU.

November:
Utsav Pandey and Mackenzie Shipley pass their candidacy exams in the Biochemistry, Microbiology, and Molecular Biology graduate program.

– The lab’s “case study” video goes live, as part of the Massive Open Online Course (MOOC) entitled: Epidemics – the Dynamics of Infectious Diseases.

October:
- Daniel Renner joins the lab as a computational scientist & bioinformatics specialist. Welcome Daniel!

– Nathan Arnett wins a 2014-2015 ECoS Undergraduate Research Support Award.

September:
- Yinan Wan, our collaborator in Istvan Albert’s group, completes the oral defense of her master’s thesis.

Mackenzie Shipley presents a talk for Virology@PSU.

August:
- Colleen Mangold joins the lab as a postdoctoral researcher, brining her expertise in neurobiology, aging, and pharmacology. Welcome Colleen!

July:
- Moriah & Chris Bowen present a poster at the 39th Annual International Herpesvirus Workshop (IHW) in Japan.

– Jacob Shreve becomes our first lab alum, as he leaves to attend medical school at Indiana University School of Medicine.

June:
- Moriah presents the lab’s current research at the University of Pennsylvania symposium, “Herpesviruses: Pathogenesis & Cancer

May:
Chris Sharkey wins an Undergraduate Summer Discovery Grant for his summer research project in the lab.

February:
- Moriah and other health researchers at Penn State build bridges with Penn State’s new visualization wall.

– PSU News carries Huck Institutes Seth Palmer’s article about our recent publication in the Journal of Virology.

January:
- Chuck Grose comments in Journal of Virology about our recent paper. He begins, “An unintended consequence of phylogenetics is that it provides answers to questions that investigators were unaware they needed to ask.…”

2013

December:
- Utsav Pandey & Mackenzie Shipley join the lab as BMMB Graduate Students.  Welcome Mackenzie & Utsav!

November:
Latest publication: “Evolution and Diversity in Human Herpes Simplex Virus Genomes” goes online at Journal of Virology.

Jacob Shreve joins the lab as Computational Scientist and bioinformatics specialist.  Welcome Jacob!

July:
Huck Institutes writer Seth Palmer profiles Szpara Lab research.

June:
Chris Bowen joins the lab as Research Technologist and lab manager.  Welcome Chris!

March:
- Beginning of the Szpara Lab at PSU

Penn State News, Cosmos, etc. (April 2016)

Forensic_virology_news

The Scientist (April 2014)

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Penn State News (February 2014)

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Huck Institutes News (February 2014)

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BMB News (March 2013)

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JoVE: Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Szpara Lab Introduction video

Lab Promo Splash

Epidemics MOOC video

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JoVE: Preparation of Viral DNA from Nucleocapsids

Jove screenshot

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